Aimée M. Dudley

CYClones is a yeast mapping population with high genetic diversity and power to detect low-heritability variants, enabling genetic dissection of complex traits.

The paper functionally profiles 2193 ASS1 missense variants to determine their pathogenicity and epistatic interactions in Citrullinemia Type I.

The paper uses a multiparent yeast population to identify QTL for growth rates across environments, revealing context-dependent genetic architectures and allelic heterogeneity.

The paper analyzes gene expression patterns in yeast colonies to understand how genetic and spatial factors influence colony structure development.

The paper predicts the functional effect of compound heterozygous genotypes using a yeast-based assay and a linear model applied to variant effect maps.

The paper develops a high-throughput functional assay to assess the impact of 1,570 OTC missense variants, improving variant interpretation using ACMG/AMP guidelines.

The paper develops a data-driven spatial model to study yeast colony growth dynamics, showing that metabolic coupling is central to colony formation.

The paper introduces a computational method and software to identify sister spores from meiotic tetrads using DNA sequence features, without requiring genetic modifications.

The paper shows that trisomy of chromosomes 5 or 6 in Candida albicans during oropharyngeal infection leads to a commensal-like phenotype with reduced virulence.

This study shows that Candida albicans rapidly generates genotypic and phenotypic diversity in the mouse oral cavity, with higher mutation rates compared to in vitro conditions.