Prime-Target neoantigen vaccination unleashes unprecedented T cell immunity within ''cold'' immunosuppressive tumors
Kou Hioki, Marlous Wildemans, Youkyung Lim, Inge Brouwers-Haspels, Marjan van Meurs, Eric M. Bindels, Harmen J.G. van de Werken, Yvonne M. Mueller, Burcu Temizoz, Ken J. Ishii, Christopher Schliehe, Peter D. Katsikis
This study demonstrates that Prime-Target neoantigen vaccination effectively overcomes immunosuppression in 'cold' tumors by enhancing T cell infiltration and reshaping the tumor microenvironment.
bioRxiv · Jan 13, 2026 · PreprintImmunology