Michael J. Davies

Spatial proteomics of the human atherosclerotic microenvironment reveals heterogeneity in intra-plaque proteomes and extracellular matrix remodeling

This paper uses spatial proteomics to reveal proteome heterogeneity and ECM remodeling in human atherosclerotic plaques across different regions.

Location-dependent proteomics of the aorta reveal an atherosclerotic disease gradient shaped by hemodynamics

The paper uses proteomics to analyze aortic regions in mice and finds protein changes associated with atherosclerotic plaque development across different anatomical sites.

Proteomics and Ex Vivo Plaque Culture Identify the Insulin-Like Growth Factor Axis as a Regulator of Carotid Plaque Stability

The paper identifies the insulin-like growth factor (IGF) axis as a regulator of carotid plaque stability through proteomic analysis and ex vivo culture experiments.

N-Terminal proteomics reveals distinct protein degradation patterns in different types of human atherosclerotic plaques

This study uses N-terminal proteomics to identify distinct protein degradation patterns in human atherosclerotic plaques, revealing differences associated with plaque stability and potential biomarkers.

Cleavage of the vascular matrix attracts glioblastoma cells to infiltrate the brain parenchyma

This study identifies LOX-mediated cleavage of the vascular matrix as a mechanism driving glioblastoma infiltration and suggests targeting LOX as a therapeutic strategy.