Thomas R. Cox

This paper shows that pulsed narmafotinib priming improves chemotherapy response in pancreatic cancer by reducing fibrosis and enhancing treatment efficacy.

This study shows that cholesterol biosynthesis is critical for myofibroblastic CAFs to remodel the extracellular matrix and promote tumor metastasis.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

This study shows that the balance between TNX and TNC, controlled by TGF-β, affects tumor cell proliferation in pancreatic cancer, suggesting TNX as a potential therapeutic target.

This study identifies LOX-mediated cleavage of the vascular matrix as a mechanism driving glioblastoma infiltration and suggests targeting LOX as a therapeutic strategy.

This study identifies ID4 as a repressor of myoepithelial differentiation in mammary stem cells through its interaction with HEB, using integrated transcriptomic, proteomic, and ChIP-sequencing data.