Author

Paul McKeigue

University of EdinburghORCID 0000-0002-5217-1034Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Bioinformatics· 1 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 4 Research Focus:GWAS / association mapping· 3 Assay:GWAS summary statistics· 3 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Athina SpiliopoulouiD· 4 shared Helen Martina ColhouniD· 3 shared Andrii IakovlieviD· 2 shared Adam M. Smiles· 1 shared Alexander Peter MaxwelliD· 1 shared Amy Jayne McKnightiD· 1 shared Andrew D. PatersoniD· 1 shared Andrew Mark McIntoshiD· 1 shared

Activity by Year

2018-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersGenetics

Athina SpiliopoulouORCID

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4 papers

Recent·Most cited

GeneticsbioRxivPreprintSep 8, 2026

Genetic trans-effects link triglyceride-rich lipoproteins to blood pressure

Svitlana Braichenko, Andrii Iakovliev, Jay Dyer…·Paul McKeigue

The paper identifies genetic trans-effects linking triglyceride-rich lipoproteins to blood pressure using GWAS and protein expression data.

DOI 10.64898/2026.09.04.749549

humanGWAS summary statistics

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Genetic & Genomic MedicinemedRxivPreprintDec 15, 2023

Inference of causal and pleiotropic effects with multiple weak genetic instruments: application to effect of adiponectin on type 2 diabetes

Paul McKeigue, Andrii Iakovliev, Athina Spiliopoulou…·Helen Martina Colhoun

The paper develops methods to improve Mendelian randomization analysis with weak and pleiotropic instruments, finding adiponectin has a causal effect on type 2 diabetes.

1 citation

humanGWAS summary statistics

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BioinformaticsTranslational PsychiatryPeer-reviewedFeb 4, 2020

Expression quantitative trait loci-derived scores and white matter microstructure in UK Biobank: a novel approach to integrating genetics and neuroimaging

Miruna C. Barbu, Athina Spiliopoulou, Marco Colombo…·Heather Clare Whalley

The paper associates eQTL-derived gene expression scores with white matter microstructure in UK Biobank, identifying 8 significant genetic proxies linked to structural connectivity traits.

12 citations

humanbulk RNA-seq

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GeneticsbioRxivPreprintDec 19, 2018

Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen

Rany M. Salem, Jennifer N. Todd, Niina Sandholm…·José C. Florez

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.

12 citations

humanGWAS summary statistics

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