Author

Yuchen Yuan

Sun Yat-sen UniversityORCID 0000-0002-5251-9942Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Assay:spatial transcriptomics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Zhonghui TangiD· 2 shared Bingling LiiD· 1 shared Chenxuan Yang· 1 shared Haitao LiiD· 1 shared Hongli DuiD· 1 shared Huida MaiD· 1 shared Jinfen WeiiD· 1 shared Ming YuaniD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCell Biology

Zhonghui TangORCID

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3 papers

Recent·Most cited

AF9/KLF2 gene regulatory circuit links histone lactylation to breast cancer metastasis

Huida Ma, Ming Yuan, Chenxuan Yang, Yuchen Yuan, Yuanyuan Li, Xin Wang, Zhonghui Tang, Haitao Li

This study identifies an AF9-KLF2 gene regulatory circuit that links histone lactylation to breast cancer metastasis by integrating metabolism, epigenetics, and signaling.

bioRxiv · Jun 18, 2025 · PreprintCell Biology

Spatial Transcriptomics Prediction from Histology jointly through Transformer and Graph Neural Networks

Yuansong Zeng, Zhuoyi Wei, Weijiang Yu, Rui Yin, Yuchen Yuan, Bingling Li, Zhonghui Tang, Yutong Lu, Yuedong Yang

Hist2ST predicts RNA-seq expression from histology images using a deep learning model combining Transformer and graph neural networks, outperforming existing methods in gene expression prediction and spatial region identification.

Briefings in Bioinformatics · Jul 17, 2022Peer-reviewedBioinformatics

Integrated analysis of gene correlation reveals disordered relationship between metabolism and immunity in tumor microenvironment

Zixi Chen, Jinfen Wei, Yuchen Yuan, Ying Cui, Yanyu Zhang, Yumin Hu, Hongli Du

The paper analyzes gene correlations between metabolism and immunity in tumor and normal tissues, finding reduced correlations in tumors and identifying key gene pairs with potential therapeutic implications.

bioRxiv · Mar 8, 2020 · PreprintBioinformatics