Haitao Li

Enhancers Silence Coupled-coding RNAs in Animals

The paper identifies regulatory non-coding genes marked by nucleosome arginine methylation and regulated by JMJD5, showing their coupling with coding genes in animals.

KMT2E recruitment by H3 serotonylation regulates neurodevelopmental chromatin dynamics

This study identifies KMT2E as a reader of H3K4me3Q5ser, showing its role in regulating chromatin dynamics and neurodevelopmental gene expression in ODLURO syndrome.

RNA reinforces condensate nucleation on chromatin to amplify oncogenic transcription

The paper shows that RNA enhances condensate formation by ENL mutants, promoting oncogenic transcription and leukemogenesis in mouse models.

Quinone reductase 2 reads H3 serotonylation to support human cortical neuron development

This study identifies QR2 as a reader of H3Q5ser, showing its role in human neuron development through transcriptional and electrophysiological effects.

AF9/KLF2 gene regulatory circuit links histone lactylation to breast cancer metastasis

This study identifies an AF9-KLF2 gene regulatory circuit that links histone lactylation to breast cancer metastasis by integrating metabolism, epigenetics, and signaling.

Single-Cell multiomics reveals ENL mutation perturbs kidney developmental trajectory by rewiring gene regulatory landscape

This study shows that an ENL mutation disrupts kidney development by altering gene regulation, leading to developmental defects and early death in mice, and suggests potential therapeutic strategies.

Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity

A single enzyme, TGM2, bidirectionally controls H3 monoaminylation dynamics, which, in turn, facilitate neural rhythmicity.

Cryo-EM Structure of R-loop monoclonal antibody S9.6 in recognizing RNA:DNA hybrids

This study determines the cryo-EM structure of the S9.6 antibody Fab bound to RNA:DNA hybrids, revealing its recognition mechanism and binding specificity.

Chromatin state barriers enforce an irreversible mammalian cell fate decision

The paper identifies a point of irreversible commitment in granulocytic differentiation and shows how chromatin state dynamics and transcription factor feedback loops influence this decision.