Zhonghui Tang

This study identifies an AF9-KLF2 gene regulatory circuit that links histone lactylation to breast cancer metastasis by integrating metabolism, epigenetics, and signaling.

Hist2ST predicts RNA-seq expression from histology images using a deep learning model combining Transformer and graph neural networks, outperforming existing methods in gene expression prediction and spatial region identification.

ChIA-PIPE is a fully automated pipeline for analyzing and visualizing ChIA-PET data, including quality assessment and visualization tools.

This study investigates how PML/RARα alters chromatin topology and transcription in APL cells, revealing its role in repressing myeloid differentiation genes.

This study examines how structural variants in 26 human populations affect 3D chromatin structure and gene transcription, showing a link between chromatin loops and transcriptional variation.

The paper identifies three span intervals of tandem duplications in TDP tumors and links them to specific gene mutations and pathways, showing TP53 and BRCA1 loss drives short-span TDPs.