Lipid nanoparticle induced model endosomal membrane disruption
Shreya Pramanik, Aishwarya Vasudevan, Zhenghua Liang, Archana Karole, Mathieu Berchel, Paul‐Alain Jaffrès, Yulia Eygeris, Gaurav Sahay
This study uses GUVs to visualize how two LNPs, LP01 and BiP-20, disrupt endosomal membranes at different pH levels, showing that bulk pKa does not predict functional membrane interaction.
bioRxiv · Sep 13, 2026 · PreprintBiophysics