Gaurav Sahay

This study uses GUVs to visualize how two LNPs, LP01 and BiP-20, disrupt endosomal membranes at different pH levels, showing that bulk pKa does not predict functional membrane interaction.

This paper evaluates an mRNA-LNP vaccine encoding BamA against N. gonorrhoeae, showing it elicits cross-reactive antibodies but lacks protective efficacy in mice.

This study shows that IL-6 enhances T cell-mediated anti-tumor immunity in pancreatic cancer by increasing lymphoid aggregates, CD4 T cells, and reducing Tregs.

The paper develops a method to deliver various RNA therapeutics, including mRNA and CRISPR-Cas9, to the lung using lipopolymer-lipid hybrid nanoparticles, showing improved efficacy and reduced toxicity.

This paper introduces a microfluidic platform for aerosolizing lipid nanoparticles without shear forces, improving mRNA delivery efficiency and safety in respiratory applications.