Timing of selective basal ganglia white matter loss in Huntington's disease
Paul Zeun, Peter McColgan, Thijs Dhollander, Sarah Gregory, Eileanoir B. Johnson, Marina Papoutsi, Akshay Nair, Rachael I. Scahill, Geraint E. Rees, Sarah J. Tabrizi, the TrackOn-HD and HD-YAS Investigators
The paper investigates WM loss in premanifest HD, finding early reductions in specific tracts 11 years before onset and correlations with motor scores.
bioRxiv · Feb 17, 2021 · PreprintNeuroscience