Rachael I. Scahill

This paper adapts Superpixel-ComBat to harmonize unpaired multi-site T1W MRI data in HD, improving image quality and enabling unified VBM analyses across scanners.

The paper investigates WM loss in premanifest HD, finding early reductions in specific tracts 11 years before onset and correlations with motor scores.

This study uses longitudinal MRI data from Huntington's Disease patients to show complex regional variations in cortical atrophy over time, with some areas showing accelerated atrophy after diagnosis.

The DPUK Data Portal provides secure access to cohort data for dementia research, supporting multi-modal analyses and collaborations across multiple institutions.

The paper evaluates graph thresholding and streamline filtering methods for structural connectome construction in Huntington's disease, finding that SIFT2 filtering improves group difference detection and clinical correlations.

This study compares functional connectome construction strategies in neurodegeneration, finding that principal component-based correction and weighted unthresholded networks best discriminate HD gene carriers from controls.