NeuroscienceScience Translational MedicinePeer-reviewed
Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.
Tracy L. Hagemann, Berit E. Powers, Ni‐Hsuan Lin…·Albee Messing
This paper introduces a new rat model of Alexander disease that exhibits key pathological features and motor impairment, demonstrating that antisense oligonucleotide therapy can reverse GFAP pathology and white matter deficits.
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