Author

Abby L. Olsen

Brigham and Women's HospitalORCID 0000-0002-7680-1758Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:Drosophila· 3 Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1 Organism:rat· 1 Approach:statistical model· 1

Frequent Co-Authors

Mel Β. FeanyiD· 2 shared A Schiro· 1 shared Ahmed F. Mohamed· 1 shared Alan M. WatsoniD· 1 shared Albee MessingiD· 1 shared Archana Marathi· 1 shared Berit E. PowersiD· 1 shared Brian D. McCabeiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersNeuroscience

Mel Β. FeanyORCID

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Author profile →

4 papers

Recent·Most cited

Genetic screening identifies glial adenosine as a therapeutic target in alpha-synucleinopathy

Maggie Sodders, E Okorie, H Tahmasebidehkordi, Archana Marathi, N Kumari, M Lakhani, A Schiro, M Shen, N Sriram, Souvarish Sarkar, Abby L. Olsen

A Drosophila genetic screen identifies glial adenosine metabolism genes as therapeutic targets for alpha-synucleinopathies by improving locomotion and reducing neurodegeneration.

bioRxiv · May 15, 2024 · PreprintNeuroscience

Sexually dimorphic mechanisms of VGLUT-mediated protection from dopaminergic neurodegeneration

Silas A. Buck, Sophie A. Rubin, Tenzin Kunkhyen, Christoph D. Treiber, Xiangning Xue, Lief E. Fenno, Samuel J. Mabry, Varun R. Sundar, Zilu Yang, Divia Shah, Kyle D. Ketchesin, Darius D. Becker‐Krail, Iaroslavna Vasylieva, Megan C. Smith, Florian J. Weisel, , Zachary Freyberg

This study identifies VGLUT-mediated mechanisms protecting DA neurons from PD-related degeneration, revealing sex-specific effects and transcriptional regulators.

bioRxiv · Oct 2, 2023 · PreprintNeuroscience

Nicotine-mediated rescue of α-synuclein toxicity requires synaptic vesicle glycoprotein 2

Abby L. Olsen, Sabrina G. Clemens, Mel Β. Feany

The paper investigates how nicotine interacts with the SV2 gene to mitigate α-synuclein toxicity in a Drosophila model of Parkinson's disease, showing that SV2 is necessary for nicotine's protective effect.

Movement Disorders · Nov 23, 2022Peer-reviewedNeuroscience

Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.

Tracy L. Hagemann, Berit E. Powers, Ni‐Hsuan Lin, Ahmed F. Mohamed, Katerina L. Dague, Seth C. Hannah, Gemma Bachmann, Curt Mazur, Frank Rigo, Abby L. Olsen, Mel Β. Feany, Ming‐Der Perng, Robert F. Berman, Albee Messing

This paper introduces a new rat model of Alexander disease that exhibits key pathological features and motor impairment, demonstrating that antisense oligonucleotide therapy can reverse GFAP pathology and white matter deficits.

Science Translational Medicine · Nov 17, 2021Peer-reviewedNeuroscience