Tracy L. Hagemann

Cellular deconvolution of the brain with topological magnetic resonance image analysis

The paper introduces STRATA, a machine learning framework that estimates cell type proportions from MRI data, validated across disease models and species.

Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment.

This paper introduces a new rat model of Alexander disease that exhibits key pathological features and motor impairment, demonstrating that antisense oligonucleotide therapy can reverse GFAP pathology and white matter deficits.

Type II Alexander disease caused by splicing errors and aberrant overexpression of an uncharacterized GFAP isoform.