Author

Xavier Suárez‐Calvet

Hospital de Sant PauORCID 0000-0002-5314-6607Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:benchmarking· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Esther Fernández‐SimóniD· 2 shared Jordi Díaz‐ManeraiD· 2 shared Patricia Piñol‐Jurado· 2 shared Alexandra MonceauiD· 1 shared Ana Carrasco‐RozasiD· 1 shared Andrés NascimentoiD· 1 shared C. OrteziD· 1 shared Carolina de la TorreiD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersBioinformatics

Esther Fernández‐SimónORCID

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintMar 1, 2023

Decoding Duchenne muscular dystrophy transcriptome to single nuclei level reveals clinical-genetic correlations

Xavier Suárez‐Calvet, Esther Fernández‐Simón, Daniel Natera‐de Benito…·Jordi Díaz‐Manera

This study uses single nuclei RNA sequencing to analyze DMD muscle samples and identifies clinical-genetic correlations by comparing gene expression profiles across cell populations.

DOI 10.1101/2023.03.01.530728

humansnRNA-seq

Molecular BiologyJournal of Cachexia Sarcopenia and MusclePeer-reviewedFeb 7, 2022

RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells in DMD

Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas…·Jordi Díaz‐Manera

This study shows PDGF-AA activates the RhoA/ROCK2 pathway in DMD fibro-adipogenic progenitor cells, leading to fibrosis, and that blocking this pathway improves muscle function in a mouse model.

25 citations

mouseproteomics