Molecular BiologyJournal of Cachexia Sarcopenia and MusclePeer-reviewed
RhoA/ROCK2 signalling is enhanced by PDGF-AA in fibro-adipogenic progenitor cells in DMD
Esther Fernández‐Simón, Xavier Suárez‐Calvet, Ana Carrasco‐Rozas…·Jordi Díaz‐Manera
This study shows PDGF-AA activates the RhoA/ROCK2 pathway in DMD fibro-adipogenic progenitor cells, leading to fibrosis, and that blocking this pathway improves muscle function in a mouse model.
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