MicrobiologybioRxivPreprint
Structures redefine the mechanism of action for tetracyclines
Swapnil C. Devarkar, Ivan B. Lomakin, Jimin Wang…·Christopher G. Bunick
This study reveals how tetracyclines target the bacterial ribosome using cryo-EM structures, showing species-specific interactions and a new mechanism for antibiotic action.
DOI 10.1101/2025.09.25.678686