Swapnil C. Devarkar

Conserved assembly architecture of the essential herpesvirus packaging accessory factor

This study presents cryo-EM structures of herpesvirus packaging accessory factors, revealing conserved pentameric symmetry and a critical positively charged central channel for genome packaging.

Visualizing the translation landscape in human cells at high resolution

The paper uses in situ cryo-EM to visualize human ribosome structures and functional states, revealing new protein interactions and polysome interfaces.

Structural insights into inhibitor mechanisms on immature HIV-1 Gag lattice revealed by high-resolution in situ single-particle cryo-EM

This study determines high-resolution structures of immature HIV-1 particles with inhibitors BVM and LEN bound using cryo-EM, revealing their distinct binding mechanisms and effects on Gag lattice architecture.

Structures redefine the mechanism of action for tetracyclines

This study reveals how tetracyclines target the bacterial ribosome using cryo-EM structures, showing species-specific interactions and a new mechanism for antibiotic action.

Nodal Modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation

This study identifies NOMO as a force-bearing ER transmembrane protein essential for muscle differentiation and ER morphology under mechanical strain.

Structural basis for aminoacylation of cellular modified tRNALys3 by human lysyl-tRNA synthetase

This study reveals the structural mechanism of human lysyl-tRNA synthetase aminoacylation of modified tRNALys3 using cryo-EM structures.

Nonstructural protein 1 of SARS-CoV-2 is a potent pathogenicity factor redirecting host protein synthesis machinery toward viral RNA.

This study identifies Nsp1 as a key pathogenicity factor of SARS-CoV-2 that redirects host translation machinery to viral RNA by inhibiting cellular protein synthesis and altering gene expression programs.