Karsten Gronert

Lipidomic Analysis Reveals Drug-Induced Lipoxins in Glaucoma Treatment

The paper identifies drug-induced lipoxins in glaucoma treatment, showing latanoprost increases lipoxin A4, which reduces inflammation and lowers intraocular pressure.

Lipoxin B4 Mitigates TRPV4-Activated Muller Cell Gliosis During Ocular Hypertension

This study shows that Muller glia produce Lipoxin B4, which suppresses TRPV4-induced gliosis and neuroinflammation in ocular hypertension.

Regulation of Diseases-Associated Microglia in the Optic Nerve by Lipoxin B4 and Ocular Hypertension

This study identifies LXB4's role in regulating microglia in the optic nerve during ocular hypertension, showing it reduces disease-associated microglia and promotes homeostasis.

Dysregulation of Neuroprotective Lipoxin Pathway in Astrocytes in Response to Cytokines and Ocular Hypertension

This study investigates how the lipoxin pathway in astrocytes is dysregulated in response to cytokines and ocular hypertension, showing that LXB4 treatment mitigates astrocyte reactivity and restores lipoxin generation.

Protective Effects of Lipoxin A4 and B4 Signaling on the Inner Retina in a Mouse Model of Experimental Glaucoma

This study shows that exogenous LXA4 and LXB4 reduce inner retinal damage in a mouse glaucoma model, with LXB4 being more effective, and that LXA4 receptor deletion worsens injury.