Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors
Rosalía Quezada Urban, Shivakumar Keerthikumar, Ashlee K. Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail Petuna Risbridger, Roxanne Toivanen, David L. Goode
This study uses single-cell RNA sequencing to show that focal neuroendocrine differentiation (Focal NED) in prostate cancer is transcriptionally distinct, characterized by androgen receptor expression and unique transcriptional sub-populations.
Molecular Oncology · Jul 24, 2025Peer-reviewedCancer Biology