The paper identifies a significant underrepresentation of South Asian ancestry breast cancer risk variants in ClinVar, highlighting a knowledge gap for this population.

Breast Cancer Research · Jan 13, 2026Peer-reviewedGenetic & Genomic Medicine

Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors

Rosalía Quezada Urban, Shivakumar Keerthikumar, Ashlee K. Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail Petuna Risbridger, Roxanne Toivanen, David L. Goode

This study uses single-cell RNA sequencing to show that focal neuroendocrine differentiation (Focal NED) in prostate cancer is transcriptionally distinct, characterized by androgen receptor expression and unique transcriptional sub-populations.

Molecular Oncology · Jul 24, 2025Peer-reviewedCancer Biology

Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins

Anna Trigos, Felicia Bongiovanni, Yangyi Zhang, Maia Zethoven, Richard W. Tothill, Richard B. Pearson, Anthony T. Papenfuss, David L. Goode

The paper shows cancer disrupts gene regulatory networks by altering co-expression between genes of unicellular and multicellular origins, with changes more pronounced in advanced tumors.

Genome biology · Apr 29, 2024Peer-reviewedBioinformatics

SPIAT: An R package for the Spatial Image Analysis of Cells in Tissues

Tianpei Yang, Volkan Ozcoban, Anu Pasam, Nikolce Kocovski, Angela Pizzolla, Yukuan Huang, Greg Bass, Simon P. Keam, Paul Joseph Neeson, Shahneen Kaur Sandhu, David L. Goode, Anna Trigos

SPIAT is an R package designed for spatial analysis of cells in tissues, offering tools for data processing, visualization, and analysis of spatially resolved single-cell data.

bioRxiv · May 28, 2020 · PreprintBioinformatics