Cancer BiologyMolecular OncologyPeer-reviewed
Defining focal neuroendocrine differentiation as a transcriptionally distinct form of prostate cancer pathology characterized by the expression of androgen receptors
Rosalía Quezada Urban, Shivakumar Keerthikumar, Ashlee K. Clark…·David L. Goode
This study uses single-cell RNA sequencing to show that focal neuroendocrine differentiation (Focal NED) in prostate cancer is transcriptionally distinct, characterized by androgen receptor expression and unique transcriptional sub-populations.