Andrew Bakshi

This paper identifies 116 risk loci for melanoma through GWAS, links susceptibility to immunity and Wnt signaling, and develops a PRS improving risk prediction.

This study uses single-cell RNA sequencing to show that focal neuroendocrine differentiation (Focal NED) in prostate cancer is transcriptionally distinct, characterized by androgen receptor expression and unique transcriptional sub-populations.

mBAT-combo improves gene-trait association detection in GWAS by accounting for SNP effect directions, revealing masking effects in complex traits.

This study evaluates a polygenic risk score for coronary heart disease in individuals aged 70 and older, finding it improves prediction when added to conventional risk factors.

A polygenic risk score predicts mosaic loss of chromosome Y in men's blood cells, with higher scores linked to increased risk.

This study evaluates a polygenic risk score for breast cancer in women aged 70 and older, finding it improves risk prediction beyond conventional factors.

The paper quantifies genetic heterogeneity between European and African populations for height and BMI, finding high shared genetic variation suggesting GWAS findings in Europeans are applicable to non-Europeans.

This study analyzes 31,396 individuals from six countries to show that genetic effects on fertility vary across time and space, with no shared genetic effects across environments.