Author

Tyler T. Pham

University of North Texas Health Science CenterORCID 0000-0002-5341-4341Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Amanda A. H. FreemaniD· 1 shared Amanda J. CrockeriD· 1 shared Avanti GokhaleiD· 1 shared Bharani NammiiD· 1 shared Carrie E. BeardeniD· 1 shared Charlene Norgan RadleriD· 1 shared Christie Sapp Savas· 1 shared Cortnie L. HartwigiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperNeuroscience

Amanda A. H. FreemanORCID

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2 papers

Recent·Most cited

CasGen: A Regularized Generative Model for CRISPR Cas Protein Design with Classification and Margin-Based Optimization

Bharani Nammi, Vindi M. Jayasinghe‐Arachchige, Sita Sirisha Madugula, Maria Artiles, Charlene Norgan Radler, Tyler T. Pham, Jin Liu, Shouyi Wang

CasGen generates novel Cas9 and Cas12 proteins using a transformer-based model with margin-based regularization, achieving structural similarity and functional integrity.

bioRxiv · Feb 28, 2025 · PreprintGenomics

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

Avanti Gokhale, Cortnie L. Hartwig, Amanda A. H. Freeman, Julia Bassell‐Hawkins, Stephanie A. Zlatic, Christie Sapp Savas, Trishna Vadlamudi, Farida Abudulai, Tyler T. Pham, Amanda J. Crocker, Erica Werner, Zhexing Wen, Gabriela M. Repetto, Joseph A. Gogos, Steven Michael Claypool, , Victor Faúndez

The paper identifies a mitochondrial transporter interactome disruption in 22q11.2 syndrome, linking it to synapse function and behavior.

Journal of Neuroscience · Jan 1, 2018Peer-reviewedNeuroscience