Carrie E. Bearden

Synaptic microRNA dysregulation orchestrates aberrant glutamatergic transmission in a human neuronal model of 22q11.2 deletion syndrome

This study identifies dysregulated synaptic microRNAs in 22q11DS neurons that drive aberrant glutamatergic transmission and synaptic plasticity, linking genetic deletion to psychosis risk.

A founder population reveals genetic variation with major effect on serious mental illness

The paper identifies a founder variant in ADAP1 associated with increased risk of schizophrenia and bipolar disorder in a Colombian genetic isolate.

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Quantitative trait loci mapping of gene expression and chromatin accessibility in primary fibroblast reveals shared allelic effects between Latin American and European ancestries

The paper maps gene expression and chromatin accessibility QTLs in fibroblasts from European and Latin American ancestries, finding high concordance and shared regulatory mechanisms.

Symptom Dimension-Specific Neurotransmitter Correlates of Psychopathology and Cognition in Early Psychosis

The paper identifies neurotransmitter systems linked to specific symptom dimensions in early psychosis using neuroimaging and PET data.

Lifespan Normative Modeling of Brain Microstructure

This paper develops a lifespan normative model of brain white matter microstructure using diffusion MRI data from 54,583 individuals, enabling detection of microstructural deviations in diseases like Alzheimer's and 22q11.2 deletion syndrome.

Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population

The paper shows that European GWAS findings for serious mental illness and cognition are portable to an admixed Latin American population, associating genetic risk scores with multiple symptoms and cognitive traits.

Combinatorial effects of gene dosage, polygenic background and environment on complex traits

The paper examines how gene dosage, polygenic background, and environment influence complex traits like height and BMI using large-scale data from multiple cohorts.

Spectral and non-spectral EEG measures in the prediction of working memory task performance and psychopathology

The paper uses EEG features beyond spectral power to predict working memory performance and psychopathology, finding that some models generalize better than others.

Genetic insights on the mechanisms of human cortical folding

This study identifies genetic maps of human sulcal complexity using rare and common variants, revealing new mechanistic pathways for cortical morphogenesis.

Convergent and Divergent Cerebellar Alterations in 22q11.2 Copy Number Variants

This study compares cerebellar volume changes in 22q11.2 deletion and duplication carriers, finding divergent structural and behavioral associations.

Gene dosage effects of 22q11.2 copy number variants on in-vivo measures of white matter axonal density and dispersion

Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis

The paper identifies a transdiagnostic functional connectivity pattern in early psychosis linked to cognitive inflexibility and arousal dysregulation across different diagnoses.

Synaptic-dependent developmental dysconnectivity in 22q11.2 deletion syndrome

This study investigates developmental dysconnectivity in 22q11.2 deletion syndrome using a cross-species approach, finding age-specific fMRI connectivity changes with synaptic origins.

Unique functional neuroimaging signatures of genetic versus clinical high risk for psychosis

The paper compares functional brain measures between 22qDel and CHR cohorts, finding distinct patterns of connectivity and variability disruptions.

Decoding Early Psychoses: Unraveling Stable Microstructural Features Associated with Psychopathology Across Independent Cohorts

The paper identifies a stable microstructural white matter signature associated with negative and somatic symptoms in early psychosis across two independent cohorts using PLS correlation.

High-effect gene-coding variants impact cognition, mental well-being, and neighborhood safety substrates in brain morphology

The paper investigates the impact of rare high-effect genetic variants on brain morphology and related behavioral traits in adolescents using the ABCD cohort.

Using rare genetic mutations to revisit structural brain asymmetry

The paper investigates how rare genetic mutations affect brain asymmetry by analyzing CNVs in a cohort of individuals and linking genetic alterations to brain structure and function.

Effects of Gene Dosage and Development on Subcortical Nuclei Volumes in Individuals with 22q11.2 Copy Number Variations

This study examines how 22q11.2 copy number variations affect subcortical brain volumes and their development across different age groups.

Attention-mediated genetic influences on psychotic symptomatology in adolescence

The paper examines how genetic risk scores relate to attentional variability and psychotic-like experiences in adolescents, finding partial mediation through attentional variability.

Longitudinal development of thalamocortical functional connectivity in 22q11.2 deletion syndrome

This study examines age-related changes in thalamocortical functional connectivity in 22q11.2 deletion syndrome and typically developing controls, finding altered developmental trajectories in specific networks.

Subcortical brain alterations in carriers of genomic copy number variants

This study examines subcortical brain alterations in CNV carriers across multiple neuropsychiatric disorders, finding shared and distinct patterns of structural changes.

Variability in cognitive task performance in early adolescence is associated with stronger between-network anticorrelation and future attention problems

This study links intra-individual variability in cognitive task performance with neural network anticorrelation and predicts future attention problems in adolescents.

Linking Choroid Plexus Enlargement with Plasma Analyte and Structural Phenotypes in Clinical High Risk for Psychosis: A Multisite Neuroimaging Study

This study finds that individuals at clinical high risk for psychosis have larger choroid plexus volumes, associated with neuroanatomical changes and plasma analyte markers.

Chromatin regulators in the TBX1 network confer risk for conotruncal heart defects in 22q11.2DS and sporadic congenital heart disease

The paper identifies chromatin regulatory genes as genetic modifiers of conotruncal heart defects in 22q11.2 deletion syndrome and links them to sporadic congenital heart disease.

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

The paper investigates how eight rare CNVs affect brain structure and phenotypes across 534 carriers, finding structural divergence and phenotypic convergence despite different genetic origins.

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

The paper investigates how molecular and connectomic vulnerabilities contribute to cortical abnormalities across multiple brain disorders using MRI data from 47,000 individuals.

Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus that are Necessary for Synapse Function

The paper shows that mitochondrial proteostasis genes in a neurodevelopmental syndrome locus are essential for synapse function and behavior in Drosophila.

Atlas of functional connectivity relationships across rare and common genetic variants, traits, and psychiatric conditions

The paper examines how rare and common genomic variants affect brain functional connectivity, revealing how polygenicity and pleiotropy influence psychiatric conditions and brain networks.

The general impact of haploinsufficiency on brain connectivity underlies the pleiotropic effect of neuropsychiatric CNVs

Neuropsychiatric CNVs reorganize brain connectivity along shared patterns linked to cognitive traits and disorder severity.