Joseph A. Gogos

Altered thalamo-prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition

This study examines how SETD1A loss-of-function affects neural synchrony in mice during a spatial working memory task, finding reduced beta-frequency synchrony between prefrontal cortex and nucleus reuniens.

In vitro reconstitution of hippocampal cell assemblies

This study demonstrates that dissociated hippocampal cells can self-organize into network dynamics similar to in vivo cognitive cell assemblies, showing resilience and response to perturbations.

Aberrant pace of cortical neuron development in brain organoids from patients with 22q11.2 deletion syndrome-associated schizophrenia

This study identifies delayed cortical neuron development in 22q11.2DS-associated schizophrenia using brain organoids and single-cell RNA sequencing.

Metabolic imprinting drives epithelial memory during mucosal fungal infection

This study identifies a metabolic-epigenetic mechanism in oral epithelial cells that enhances protection against fungal infection through proline catabolism and mitochondrial function.

An antisense oligonucleotide-based strategy to ameliorate cognitive dysfunction in the 22q11.2 Deletion Syndrome

This study shows that reducing EMC10 levels in 22q11.2 deletion syndrome models improves cognitive function and sustains benefits for over two months.

Genomic and Transcriptomic Signatures of SETD1A Disruption in Human Excitatory Neuron Development and Psychiatric Disease Risk

This study investigates how SETD1A disruption affects gene regulation and neurodevelopment, linking it to schizophrenia risk through chromatin and transcriptomic analyses in human organoids.

Assigning Targetable Pathways to Transdiagnostic Subgroups Across Neurodevelopmental Disorders

The paper identifies molecular pathways associated with neurodevelopmental disorder subgroups using neuroimaging data from mice and humans.

Cortical assembloids support the development of fast-spiking human PVALB+ cortical interneurons and uncover schizophrenia-associated defects

The paper develops a cortical assembloid system to study human PVALB+ interneuron development and identifies schizophrenia-associated defects in their migration and molecular profiles.

Interhemispheric CA1 projections support spatial cognition and are affected in a mouse model of the 22q11.2 deletion syndrome

This study identifies a novel interhemispheric CA1 projection to the dorsal subiculum that supports spatial memory and is disrupted in a mouse model of 22q11.2 deletion syndrome.

Disorganized Inhibitory Dynamics in Hippocampal area CA1 of 22q11.2 Deletion Mutant Mice

The paper examines inhibitory interneuron dynamics in 22q11.2 deletion mutant mice during spatial tasks, finding subtype-specific disruptions in activity and microcircuit organization.

AUTS2 gene dosage affects synaptic AMPA receptors via a local dendritic spine AUTS2-TTC3-AKT-mTORC1 signaling dysfunction

This study shows that AUTS2 gene dosage affects synaptic AMPA receptors through the AUTS2-TTC3-AKT-mTORC1 pathway, leading to behavioral and cognitive impairments in mice.

Vascular-Derived SPARC and SerpinE1 Regulate Interneuron Tangential Migration and Accelerate Functional Maturation of Human Stem Cell-Derived Interneurons

Recapitulation and reversal of schizophrenia-related phenotypes in Setd1a-deficient mice

This study shows that Setd1a-deficient mice exhibit schizophrenia-like phenotypes, which can be reversed by restoring Setd1a expression or inhibiting LSD1.

Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior

The paper identifies a mitochondrial transporter interactome disruption in 22q11.2 syndrome, linking it to synapse function and behavior.