CACHE Challenge #1: targeting the WDR domain of LRRK2, a Parkinson's Disease associated protein.
Fengling Li, Suzanne Z. Ackloo, C. H. Arrowsmith, Fuqiang Ban, Christopher Barden, Hartmut Beck, Jan Beránek, Francois Berenger, Albina Bolotokova, Guillaume Bret, Marko Breznik, Emanuele Carosati, Irene Chau, Yu Chen, Artem R Cherkasov, , Matthieu Schapira
The paper evaluates computational hit-finding methods for targeting the WDR domain of LRRK2, a Parkinson's disease protein, finding that diverse strategies yielded weakly potent compounds.
Journal of Chemical Information and Modeling · Nov 5, 2024Peer-reviewedBiochemistry