The dietary emulsifier polysorbate-80 induces lipid accumulation and cell death in intestinal epithelial cells via ferroptosis
Gonzalo Saiz-Gonzalo, Raminder Singh, Naomi Hanrahan, Gaston L. Cluzel, Cian Manning, Karina Quilter, Tadhg Crowley, Dagmar Šrůtková, Tomáš Hudcovic, Martin Schwarzer, Simone Marcone, Jacintha O’Sullivan, Susan A. Joyce, Silvia Melgar
This study shows that polysorbate-80 induces ferroptosis in intestinal epithelial cells by disrupting lipid homeostasis, leading to cell death and potential contributions to chronic diseases.
bioRxiv · Aug 29, 2025 · PreprintCell Biology