Author

Jacintha O’Sullivan

Trinity College Dublin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Alexander RA AndersoniD· 1 shared Bina DesaiiD· 1 shared Cian Manning· 1 shared Cliona O’FarrellyiD· 1 shared Dagmar ŠrůtkováiD· 1 shared Gaston L. CluzeliD· 1 shared Gonzalo Saiz-GonzaloiD· 1 shared Jeffrey WestiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperCancer Biology

Alexander RA AndersonORCID

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Author profile →

2 papers

Recent·Most cited

The dietary emulsifier polysorbate-80 induces lipid accumulation and cell death in intestinal epithelial cells via ferroptosis

Gonzalo Saiz-Gonzalo, Raminder Singh, Naomi Hanrahan, Gaston L. Cluzel, Cian Manning, Karina Quilter, Tadhg Crowley, Dagmar Šrůtková, Tomáš Hudcovic, Martin Schwarzer, Simone Marcone, Jacintha O’Sullivan, Susan A. Joyce, Silvia Melgar

This study shows that polysorbate-80 induces ferroptosis in intestinal epithelial cells by disrupting lipid homeostasis, leading to cell death and potential contributions to chronic diseases.

bioRxiv · Aug 29, 2025 · PreprintCell Biology

Evolutionary double-bind treatment using radiotherapy and NK cell-based immunotherapy in prostate cancer

Kimberly A Luddy, Jeffrey West, Mark Robertson-Tessi, Bina Desai, Taylor M. Bursell, Sarah Barrett, Jacintha O’Sullivan, Laure Marignol, Robert A Gatenby, Joel S Brown, Alexander RA Anderson, Cliona O’Farrelly

This study combines radiotherapy and NK cell immunotherapy to exploit an evolutionary double-bind strategy in prostate cancer, showing that RT-resistant cells become more vulnerable to NK cell killing.

bioRxiv · Mar 11, 2024 · PreprintCancer Biology