Author

Silvia Melgar

University College CorkORCID 0000-0001-7463-3343Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Tadhg CrowleyiD· 2 shared Agnieszka SkowyraiD· 1 shared Amanda J. LohaniD· 1 shared Ana Ramón-Vázquez· 1 shared Andrew J. LindsayiD· 1 shared Bradford L. McRae· 1 shared Cian Manning· 1 shared Ciaran M. LeeiD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Tadhg CrowleyORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintAug 29, 2025

The dietary emulsifier polysorbate-80 induces lipid accumulation and cell death in intestinal epithelial cells via ferroptosis

Gonzalo Saiz-Gonzalo, Raminder Singh, Naomi Hanrahan…·Silvia Melgar

This study shows that polysorbate-80 induces ferroptosis in intestinal epithelial cells by disrupting lipid homeostasis, leading to cell death and potential contributions to chronic diseases.

DOI 10.1101/2025.08.29.673091

humanbulk RNA-seq

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ImmunologybioRxivPreprintMay 29, 2025

IL-32 drives inflammatory responses in IFN-γ primed human macrophages via a Myddosome-dependent pathway and is elevated in COVID-19

Ana Ramón-Vázquez, Agnieszka Skowyra, Tadhg Crowley…·Kenneth Nally

This study identifies IL-32β as a ligand that primes human macrophages for M1-like inflammatory responses via a Myddosome-dependent pathway and shows elevated IL-32 in severe COVID-19.

DOI 10.1101/2025.05.29.656795

humanproteomics

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