Pharmacologic NLRP3 Inhibition Modulates Parkinson's Disease-Associated Microglial Transcriptomic Signatures and Mitigates α-Synuclein-Triggered Neurodegeneration
María Luque, Magdalena Matic, Antonio Heras‐Garvin, Jesús Amo‐Aparicio, Kelvin C. Luk, Michaela Tanja Haindl, Michael Khalil, Damaris B. Skouras, Charles Anthony Dinarello, Nadia Stefanova
This study evaluates dapansutrile, an NLRP3 inhibitor, in preclinical models of Parkinson's disease and multiple system atrophy, showing improved motor function, reduced neurodegeneration, and transcriptomic changes in microglia.
Journal of Neuroinflammation · Jan 31, 2026Peer-reviewedNeuroscience