Nadia Stefanova

This paper develops an RNA aptamer, 1R6, that targets synuclein and shows therapeutic potential in synucleinopathies by inhibiting aggregation and promoting disaggregation.

The paper uses imaging transcriptomics in a mouse model of MSA to link MRI patterns with gene expression, identifying molecular correlates of neurodegeneration.

This study evaluates dapansutrile, an NLRP3 inhibitor, in preclinical models of Parkinson's disease and multiple system atrophy, showing improved motor function, reduced neurodegeneration, and transcriptomic changes in microglia.

The paper investigates the role of oligodendroglial-derived extracellular vesicles in spreading pathology in MSA-like models, showing they carry pathological Synuclein and TPPP/p25 and induce disease in animal models.

This paper develops an iPSC platform to rapidly generate alpha-synuclein inclusions and investigates their formation, subtypes, and molecular interactions.

This study shows that different a-Synuclein strains influence MSA progression through central and peripheral immune mechanisms, with strain-dependent effects on neurodegeneration and glial responses.

This study profiles RNA expression in MSA cerebellar tissue, identifying distinct transcriptional signatures between parkinsonian and cerebellar subtypes, with greater dysregulation observed in the cerebellar subtype.

This study identifies shared genetic loci between multiple system atrophy and inflammatory bowel disease using conjFDR, highlighting immune and gut-related molecular mechanisms.