Charles Anthony Dinarello

OLT1177 (Dapansutrile) inhibits Gasdermin D-dependent IL-1β Release and Pyroptotic Cell Death in Bone Marrow-derived Macrophages

OLT1177 inhibits IL-1β release and pyroptotic cell death in LPS-treated BMDMs by blocking caspase-1 and GSDMD activation.

Pharmacologic NLRP3 Inhibition Modulates Parkinson's Disease-Associated Microglial Transcriptomic Signatures and Mitigates α-Synuclein-Triggered Neurodegeneration

This study evaluates dapansutrile, an NLRP3 inhibitor, in preclinical models of Parkinson's disease and multiple system atrophy, showing improved motor function, reduced neurodegeneration, and transcriptomic changes in microglia.

Inflammation promotes aging-associated oncogenesis in the lung.

This study investigates how aging-related inflammation contributes to lung cancer development by analyzing gene expression data and using mouse models to assess the role of inflammation in oncogenesis.

IL-37 expression reduces acute and chronic neuroinflammation and rescues cognitive impairment in an Alzheimer s disease mouse model

Impact of rare and common genetic variation in theInterleukin-1 pathway for human cytokine responses

This study identifies associations between rare and common genetic variants in the IL-1 pathway and cytokine responses to various stimuli in healthy individuals.