Mitochondrial activity directs nutrient uptake to control early human embryonic patterning
Shiyu Bian, Marta M Marcheluk, Ana Reiry Marques Lima, Songyang Li, Christopher J. Price, Véronique Azuara, Ivana Barbaric, Tristan A. Rodríguez
The paper shows mitochondrial activity regulates nutrient uptake, affecting BMP4 signaling and spatial organization of germ layers in human gastruloids.
bioRxiv · Jul 4, 2026 · PreprintDevelopmental Biology