Tristan A. Rodríguez

The paper shows mitochondrial activity regulates nutrient uptake, affecting BMP4 signaling and spatial organization of germ layers in human gastruloids.

This study identifies MTFP1 as critical for β-cell mitochondrial structure and function, essential for insulin secretion and glucose homeostasis, and shows its role as a downstream effector of miR-125b.

The paper shows that winner cells in cell competition induce L-Proline uptake in loser cells, repressing the integrated stress response and leading to their elimination.

This paper shows that deleting Mfn1 and Mfn2 in beta cells impairs mitochondrial structure and insulin secretion, but incretins can partially compensate through EPAC2 signaling.

The paper shows that p53-deficient embryonic stem cells outcompete wild-type cells during differentiation, eliminating them via apoptosis through local interactions.

The paper identifies mitochondrial defects in eliminated cells during early mouse development and shows that cell competition removes cells with mitochondrial DNA mutations and sequence changes.

The paper identifies a conserved serine in UBE2D3 that, when phosphorylated by Aurora B, reduces UBE2D3 levels and affects early embryonic development in mice.

This study identifies DRP1-mediated mitochondrial dynamics as a regulator of apoptotic response during embryonic differentiation in mouse cells.