This study identifies a non-transferable NLS in pSTAT1 that requires importin 5, Ran-GTP, and CAS for nuclear translocation and release, revealing a novel mechanism for cytokine-induced STAT1 signaling.

bioRxiv · Sep 29, 2026 · PreprintBiochemistry

Insights into Genome Ejection by a Therapeutic phiKMV-like Bacteriophage

Junwei Li, Nathan F. Bellis, Ravi K. Lokareddy, Chun-Feng David Hou, Steven D. Branston, Zsuzsanna Kovách, Renae R. Geier, A.B. Soriaga, Lucy Sim, Pierre A. Kyme, Deborah L. Birx, Sébastien Lemire, Gino Cingolani

This paper presents an integrative structural analysis of the bacteriophage Ar-KM, revealing structural polymorphism and the role of ejection proteins in genome ejection.

Journal of Molecular Biology · Aug 18, 2026Peer-reviewedBiophysics

Structural atlas of Pakpunavirus P7-1 reveals determinants of virion stability and genome ejection

Fenglin Li, Nathan F. Bellis, Ravi K. Lokareddy, Chun-Feng David Hou, Ruoyu Yang, Steven D. Branston, Zsuzsanna Kovach, Renae R. Geier, A.B. Soriaga, Lucy Sim, Pierre A. Kyme, Deborah L. Birx, Sébastien Lemire, Gino Cingolani

The paper presents a structural atlas of the Pakpunavirus P7-1 phage, identifying key structural components and their roles in virion stability and genome ejection.

Communications Biology · Apr 30, 2026Peer-reviewedBiochemistry

High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223

Chun-Feng David Hou, Nathan F. Bellis, Ravi K. Lokareddy, Steven D. Branston, Johnny Reid, Renae R. Geier, A.B. Soriaga, Lucy Sim, Pierre A. Kyme, Deborah L. Birx, Sébastien Lemire, Gino Cingolani

This paper presents a high-resolution cryo-EM structure of the Pseudomonas phage Pa223, revealing hybrid structural features shared with P22-like, T7-like, and Litunavirus phages.

bioRxiv · Jun 11, 2025Biochemistry