Cytokine-induced nuclear translocation of STAT1 via a non-transferable NLS
Pramod Kumar, James R. Cavey, Ruoyu Yang, Oran White, Andreas Begitt, Liu He, Stephanie S. Suinn, Nathan F. Bellis, Ravi K. Lokareddy, Uwe Vinkemeier, Gino Cingolani
This study identifies a non-transferable NLS in pSTAT1 that requires importin 5, Ran-GTP, and CAS for nuclear translocation and release, revealing a novel mechanism for cytokine-induced STAT1 signaling.
bioRxiv · Sep 29, 2026 · PreprintBiochemistry