Gino Cingolani

Engineered Chimeric Proteins Functionally Replace ALS-causing Endogenous FUS and TDP-43 to Improve Neuronal Health

The paper engineers chimeric proteins to replace ALS-causing FUS and TDP-43, improving neuronal health by reducing aggregation and restoring nuclear functions.

Cytokine-induced nuclear translocation of STAT1 via a non-transferable NLS

This study identifies a non-transferable NLS in pSTAT1 that requires importin 5, Ran-GTP, and CAS for nuclear translocation and release, revealing a novel mechanism for cytokine-induced STAT1 signaling.

Insights into Genome Ejection by a Therapeutic phiKMV-like Bacteriophage

This paper presents an integrative structural analysis of the bacteriophage Ar-KM, revealing structural polymorphism and the role of ejection proteins in genome ejection.

Structural atlas of Pakpunavirus P7-1 reveals determinants of virion stability and genome ejection

The paper presents a structural atlas of the Pakpunavirus P7-1 phage, identifying key structural components and their roles in virion stability and genome ejection.

High-resolution cryo-EM analysis of the therapeutic Pseudomonas phage Pa223

This paper presents a high-resolution cryo-EM structure of the Pseudomonas phage Pa223, revealing hybrid structural features shared with P22-like, T7-like, and Litunavirus phages.

Simulations and Electrostatic Analysis Suggest an Active Role for DNA Conformational Changes During Genome Packaging by Bacteriophages

The paper uses computational simulations to show DNA conformational changes driven by electrostatic potential shifts in bacteriophage packaging motors, linking ATP hydrolysis to DNA translocation.