Multiciliated cells adapt the mechanochemical Piezo1-Erk1/2-Yap1 cell proliferation axis to fine-tune centriole number.
Vani Narayanan, Venkatramanan G. Rao, Angelo B. Arrigo, Saurabh S. Kulkarni
This study identifies the mechanochemical Piezo1-Erk1/2-Yap1 pathway in multiciliated cells that regulates centriole amplification through tension-dependent activation of Foxj1.
bioRxiv · Jan 21, 2025 · PreprintCell Biology