Saurabh S. Kulkarni

Microtubule-templated actin assembly by septin9 drives apical expansion of epithelial cells

This study shows that Septin9, associated with microtubules, drives actin assembly and apical expansion in epithelial cells during morphogenesis.

Patient-informed CRISPR Screen Identifies FLNB as a Novel Congenital Heart Disease and Ciliopathy Gene

The paper uses a CRISPR screen in Xenopus to identify FLNB as a novel gene associated with congenital heart disease and ciliopathies.

Compound heterozygous DAW1 variants reveal tissue-specific roles in left-right patterning and congenital heart disease without primary ciliary dyskinesia

The paper identifies DAW1 variants in a patient with heterotaxy and congenital heart disease, showing tissue-specific functional effects without primary ciliary dyskinesia.

Integrative Functional Genomics Identifies ARHGAP10 in the 4q31.2 Locus as a Novel Congenital Heart Disease and Ciliopathy Gene.

This study identifies ARHGAP10 as a novel gene associated with congenital heart disease and ciliopathy through integrative functional genomics in Xenopus tropicalis.

Multiciliated cells adapt the mechanochemical Piezo1-Erk1/2-Yap1 cell proliferation axis to fine-tune centriole number.

This study identifies the mechanochemical Piezo1-Erk1/2-Yap1 pathway in multiciliated cells that regulates centriole amplification through tension-dependent activation of Foxj1.

The Heterotaxy Gene, CCDC11, is Essential for Cytokinesis and Cell-Cell Adhesion Via RhoA Regulation

This study shows CCDC11 is essential for cytokinesis and cell-cell adhesion via RhoA regulation, linking it to heterotaxy disease pathogenesis.

WDR5 stabilizes actin architecture to promote multiciliated cell formation

The paper identifies WDR5's role in stabilizing apical actin architecture to support multiciliated cell formation and function.