GenomicsbioRxivPreprint
Influence of sequencing depth on the fidelity and sensitivity of 1%-5% low-frequency mutation detection and recommendation for standardization of sequencing depth
Zhe Liu, Weijin Qiu, Shujin Fu…·Fang Chen
This paper investigates how sequencing depth affects low-frequency mutation detection, showing that increasing depth improves fidelity and sensitivity while reducing false positives.
DOI 10.1101/2021.12.26.474219