Brock A. Peters

A little longer, a lot better: simulation-guided exploration of extended-length single-end barcoded reads for structural variant detection

This study evaluates long single-end barcoded reads for structural variant detection, showing improved accuracy with longer read lengths compared to short-read and pangenome-based methods.

Capture-C MPRA: A high-throughput method to simultaneously characterize promoter interactions and regulatory activity

This paper introduces ccMPRA, a method that combines Capture-C and MPRA to study promoter interactions and regulatory activity, identifying enhancers and silencers.

Assembly and analysis of the genome of Notholithocarpus densiflorus

The paper assembles the genome of Notholithocarpus densiflorus and identifies genetic variation across 11 individuals with varying susceptibility to sudden oak death.

Comparison of long read methods for sequencing and assembly of a plant genome

This study compares three long-read sequencing technologies for de novo assembly of the Macadamia jansenii genome, evaluating contiguity, accuracy, completeness, cost, and DNA requirements.

A portable and cost-effective microfluidic system for massively parallel single-cell transcriptome profiling

The DNBelab C4 portable, negative-pressure microfluidic device performs high-throughput single-cell transcriptome profiling, resolving species-specific cells and tissue heterogeneity in murine lung and cerebral cortex comparably to existing platforms.

An ATAC-seq atlas of chromatin accessibility in mouse tissues

The paper creates an ATAC-seq atlas of chromatin accessibility in adult mouse tissues, identifying tissue-specific accessible elements and transcription factor motifs.

Efficient long single molecule sequencing for cost effective and accurate sequencing, haplotyping, and de novo assembly

This paper introduces stLFR, a low-cost method for long DNA sequencing that enables accurate variant calling, haplotyping, and de novo assembly.

3’ Branch Ligation: A Novel Method to Ligate Non-Complementary DNA to Recessed or Internal 3’OH Ends in DNA or RNA

The paper introduces a novel ligation method called 3BL that allows non-complementary DNA to be ligated to 3' ends of DNA or RNA, improving NGS library construction by reducing adapter dimer issues and increasing yield.

Advanced whole genome sequencing and analysis of fetal genomes from amniotic fluid

This study demonstrates the feasibility of whole genome sequencing of fetal genomes from amniotic fluid, revealing additional genetic and clinical information beyond chromosomal abnormalities.

Significant abundance of cis configurations of mutations in diploid human genomes

The paper analyzes mutation phase in diploid human genomes and finds that protein-altering mutations are significantly more common in cis than trans configurations across diverse populations.