Fang Chen

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

The paper develops a resource to improve cardiac modelling protocols using hPSC-CMs by analyzing decades of research data and providing tools for protocol benchmarking.

Intra-genomic genes-to-genes correlation enables genome representation

The paper shows that combinations of highly variable core genes can accurately predict sequence variants and antibiotic resistance in bacterial genomes.

Whole-exome Sequencing Study of Hypospadias

The paper identifies rare damaging variants in outer DNAH genes in 22.5% of severe hypospadias patients, suggesting their role in the condition and potential for genetic counseling.

Influence of sequencing depth on the fidelity and sensitivity of 1%-5% low-frequency mutation detection and recommendation for standardization of sequencing depth

This paper investigates how sequencing depth affects low-frequency mutation detection, showing that increasing depth improves fidelity and sensitivity while reducing false positives.

SLR-superscaffolder: a de novo scaffolding tool for synthetic long reads using a top-to-bottom scheme

The paper introduces a de novo scaffolding tool for synthetic long reads that improves assembly quality significantly, especially for assemblies from next-generation sequencing reads.

Effect of storage conditions on peripheral leukocytes transcriptome

This study assesses how temporary storage conditions affect the transcriptome of peripheral blood leukocytes, identifying gene expression changes and stable reference genes.

Single cell chromatin accessibility of the developmental cephalochordate

This study creates the first single-cell chromatin accessibility atlas of the lancelet, revealing regulatory elements and developmental trajectories.

Single cell atlas of trisomy 21 cerebral cortex

This study creates the first single cell atlas of T21 cerebral cortex, identifying dysregulated genes and developing a platform for data exploration.

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

This study creates the first single-cell brain atlas of domestic pigs, identifies cell types and their spatial distribution, and compares them with other species to reveal evolutionary and disease-related insights.

Compensatory replacement of the BigH1 variant histone by canonical H1 supports normal embryonic development in Drosophila

The paper shows that maternal H1 can compensate for the absence of BigH1 in Drosophila embryos, supporting normal development.

Assessment of the gene expression profiles of leukocytes from different isolations

This study compares gene expression profiles of leukocytes from different isolation methods, finding that RBC lysis reduces globin mRNA and improves transcriptome quality.

Single-cell Transcriptomic Landscape of Nucleated Cells in Umbilical Cord Blood

The paper presents a single-cell transcriptomic analysis of nucleated cells in umbilical cord blood, identifying cell types, subpopulations, and transcriptional programs that may impact transplant outcomes.