Subunit specialisation in AAA+ proteins and substrate unfolding during transcription complex remodelling
Forson Gao, Fuzhou Ye, Martin Buck, Xiaodong Zhang
This study reveals the mechanism of DNA melting during transcription initiation by σ54-mediated open complex formation, showing how bEBP ATP hydrolysis drives σ54 unfolding and promoter DNA melting.
bioRxiv · Feb 15, 2025 · PreprintBiochemistry