Systems BiologyCancer ResearchPeer-reviewed
Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia
David Eugene Frankhouser, Dandan Zhao, Yu-Hsuan Fu…·Guido Marcucci
The paper shows that clinically relevant leukemia phenotypes emerge at the macrostate level from single cell data, revealing how disease states aggregate from noisy single cell transcriptomes.