Anupam Dey

Cell cycling throttles epithelial--mesenchymal transition

This study shows that G1 phase cells exhibit stronger EMT gene expression and RNA velocity than cycling cells, suggesting cell cycle phase influences EMT and should not be regressed out.

A Mecom—Cdk6 toggle switch governs hematopoietic stem-to-multipotent fate transitions via distinct multistable landscapes

The paper models the Mecom-Cdk6 regulatory network to show how IGF signaling and self-activation shape stem cell fate transitions through multistable landscapes.

Longitudinal single cell RNA-sequencing reveals evolution of micro- and macro-states in chronic myeloid leukemia

The paper shows that clinically relevant leukemia phenotypes emerge at the macrostate level from single cell data, revealing how disease states aggregate from noisy single cell transcriptomes.

Transition paths across the EMT landscape are dictated by network logic

The paper investigates how network logic (additive vs multiplicative) influences EMT transitions and shows that AND logic better matches experimental data on miR-200 regulation.