Author

Juan Antonio García‐León

Biomedical Research Networking Center on Neurodegenerative DiseasesORCID 0000-0002-5410-3377Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Alfredo BruscoiD· 1 shared Annalisa BuffoiD· 1 shared Arianna Contato· 1 shared Boyu ReniD· 1 shared Bruce M. CoheniD· 1 shared Catherine M. VerfaillieiD· 1 shared Donna L. McPhieiD· 1 shared Elena SignorinoiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperNeuroscience

Alfredo BruscoORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 15, 2026

Functional validation of allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic option for Autosomal Dominant Leukodystrophy

Martina Lorenzati, Arianna Contato, Fernando Josa‐Prado…·Annalisa Buffo

This study validates allele-specific LMNB1 silencing in patient-derived astrocytes as a therapeutic approach for ADLD by showing restored physiological levels and functional improvements.

DOI 10.64898/2026.09.09.747273

humanbulk RNA-seq

NeurosciencebioRxivPreprintJun 14, 2022

SOX10 Expression Levels may be a Critical Mediator of White Matter Dysfunction in Schizophrenia.

Donna L. McPhie, Boyu Ren, Juan Antonio García‐León…·Bruce M. Cohen

The paper investigates SOX10 expression levels in schizophrenia and finds reduced SOX10 correlates with oligodendrocyte dysfunction and impaired white matter.

DOI 10.1101/2022.06.14.496174

humanbulk RNA-seq