Catherine M. Verfaillie

This paper introduces a scalable 3D liver model using hiPSC-derived organoids to predict drug toxicity, showing comparable functionality to primary hepatocytes.

This paper introduces human myelin spheres (MyS) as a model for studying myelination and demyelination, showing their ability to form myelinated neurons and mimic in vivo oligodendrocyte development.

MyeliMAP models human CNS myelination using hPSC-derived neurons and oligodendrocytes in a microfluidic platform, showing enhanced action potential conduction and stabilized network activity.

This study investigates the role of oligodendroglia in Wolfram syndrome using mouse models and iPSC-derived cells, finding preserved oligodendroglia function and suggesting alternative targets for treatment.

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

This study shows that hyperosmolar conditions induce cell cycle exit and differentiation in pluripotent cells through NF-κB and WNT signaling pathways.

The paper investigates DNA methylation and transcriptomic changes in chronic demyelinated MS lesions, showing hypermethylation of myelination-related genes and demonstrating reversible effects through epigenetic editing.

This study shows that Wnt/TCF7L1 repression promotes primitive endoderm differentiation in mESCs by inhibiting naive and formative pluripotency factors.

The paper investigates SOX10 expression levels in schizophrenia and finds reduced SOX10 correlates with oligodendrocyte dysfunction and impaired white matter.

This study uses DMD patient iPSCs to model cardiomyopathy, identifies NOX4 as a therapeutic target due to its role in ROS production, and shows interventions that reduce oxidative stress and improve cell survival.

This study shows that C9orf72 repeat expansions produce toxic arginine-rich DPRs that disrupt axonal transport by interacting with microtubules and motor proteins, contributing to ALS/FTD.

The paper introduces a computational tool to identify key transcription factors in lineage specification and validates PU.1 as a master regulator for generating LSEC-like cells from pluripotent stem cells.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.