Contrasting approaches to genome-wide association studies impact the detection of resistance mechanisms in Staphylococcus aureus
Nicole E. Wheeler, Sandra Reuter, Claire Chewapreecha, John A. Lees, Beth Blane, Carolyne Horner, David Enoch, Nicholas M. Brown, M. Estée Török, David M. Aanensen, Julian Parkhill, Sharon J. Peacock
The paper evaluates GWAS methods for detecting antibiotic resistance in Staphylococcus aureus genomes, finding they identify novel resistance mutations but are less accurate than literature-based approaches.
bioRxiv · Sep 4, 2019 · PreprintBioinformatics